Though many group Donora in a class of Western Pennsylvania towns and cities known collectively as the “rust belt” because of the demise of the once prolific steel industry, the town continues to be a center for industry and manufacturing. On the site of the former steel mills now stands a large industrial park that is managed by MMIDA (Mid Mon Valley Industrial Development Authority).

Major companies that have facilities in the Donora Industrial Park include A-1 Babbit company, Apex North America, Area Agency on Aging, Bergen Power Pipe Supports, Fresenius Kidney Care, HYTEC Inc., Dyno-Nobel Inc, Eastern Alloy, Eastern Hydraulic & Machine, Elizabeth Milling Corporation, Elliott Support Services, Glosser Industries, Industrial Nonferrous Casting Company, K-Z Tool Company, Airgas Specialty Products, Inc. (formerly LaRoche Industries), McGrew Welding Fabrication, Metalife Resources, MIDA Inc., Mon Valley Child Care, Mon Valley Sewage Authority, Power & Industrial Services Corporation, Nichols Miniatures, Pittsburgh Post Gazette Distribution Center, RAS Industries Inc., Regal Industries Inc., RETAL, and Barchemy.